Public Page - Esta Sterneck

Member Bio:

Dr. Sterneck grew up in Graz (Austria) and studied biology in Munich and Heidelberg (Germany). She received her Ph.D. from the University of Heidelberg following training at the European Molecular Biology Laboratory (EMBL) and the Center for Molecular Biology Heidelberg (ZMBH) in Germany. Her thesis work investigated oncogene cooperation in leukemia cells and revealed their coordinate induction of an essential autocrine growth factor. During her postdoctoral training at the Advanced BioScience Laboratories-Basic Research Program in Frederick, MD (USA) Dr. Sterneck began to study the functions of specific transcription factors and their roles in normal mammary gland development. Dr. Sterneck began her independent research with an NCI-Scholar grant before being recruited as a Principal Investigator to the NCI in 2003. Dr. Sterneck's research group investigates cell signaling pathways that regulate mammary gland development and tumorigenesis. Work with transgenic mouse models, human cancer cell lines, and patient-derived xenograft models addresses the mechanisms by which inflammation, stress, and hypoxia shape the progression and metastasis of breast cancer. Studies of the C/EBP family of transcription factors elucidated intersections of signaling pathways that contribute to the malignancy of cancer cells. Current investigations include analyses of the immune system response to tumors, especially by the myleoid lineage. The ultimate goal is to uncover actionable vulnerabilities of established breast cancer metastase