Jana M. Kainerstorfer, Ph.D., Associate Professor, Department of Biomedical Engineering, Neuroscience Institute
Electrical & Computer Engineering (courtesy), Carnegie Mellon University
February 26, 2021, 12:00 PM EST
Bedside monitoring of tissue perfusion is important for a variety of diseases. For cerebral monitoring, cerebral perfusion is important especially for traumatic brain injury, hydrocephalus, sepsis, and stroke, where inadequate perfusion can lead to ischemia and neuronal damage. Diffuse optical methods, such as near-infrared spectroscopy and diffuse correlation spectroscopy, are non-invasive optical techniques which can be used to measure cerebral changes at the bedside. This talk will focus on these optical techniques as applied to clinical measurements to monitor patients and predict treatment outcome. One example of such will be presented which is our recent developments of a non-invasive intracranial pressure (ICP) sensor. Our results show that ICP could be extracted to within ~4 mmHg, making this a clinically useful tool with the opportunity to replace invasive ICP sensors. This talk will summarize our optical imaging methods, experimental procedures, and results, as well as the path towards clinical translation.
Jana Kainerstorfer is an Associate Professor of Biomedical Engineering at Carnegie Mellon University and holds courtesy appointments in the Neuroscience Institute and Electrical & Computer Engineering. She earned a PhD in Physics from the University of Vienna in Austria in partnership with the National Institutes of Health and worked as a postdoctoral fellow at Tufts University. Her lab’s research is focused on developing noninvasive optical imaging methods for disease detection and/or treatment monitoring, with an emphasis on diffuse optical imaging. She serves on program committees at national and international conferences (including the SPIE Photonics West as well as OSA Topical Meetings) and served as Program Chair for the OSA Biophotonics Congress: Optical Tomography and Spectroscopy in 2020. She further is an associate editor for Journal of Biomedical Optics (SPIE), served as associated editor for IEEE Transactions on Biomedical Engineering. Her research has been funded by AHA, NIH, ONR, DARPA, and the Air Force, including the NIH R21 Trailblazer as well as AHA Scientist Development Grant.